I love my 2018 MBP + eGPU setup to the point that I chuckle whenever I see people claiming how awful these MBPs are. I've googled around and it appears like other people are also having this issue with QuickLookUIService. I uninstalled the app and everything went back to normal. In my case there was a QuickLook plugin from a recently installed trial app that was preventing the eGPU from disconnecting. If it does, you probably have a buggy QuickLook plugin with one or more apps. If you're having disconnect issues I'd urge you to see if killing the QuickLookUIService process causes the eGPU to immediately disconnect. I've been using an eGPU (15" 2018 MBP i9, RX 580, 10.14.x) for over half a year and only ran into connect/disconnect issues once. Using a desktop machine at the office for work has improved my work-life balance, and my productivity. Now I don't have to carry a bag to work, and my home laptop can cover things in a pinch. I still use the old MacBook Pro at home, but it's not my daily machine. It seemed to improve overall OSX responsiveness too, but perhaps that's just the new Mac Mini in action. If you're doing visual stuff, it's the budget version of a Mac Pro. I switched to a Mac Mini at work (stock GPU build of course) with the same enclosure and graphics card, and the experience has been pretty delightful. The connect/disconnect experience is really flaky, and you'll probably spend a few times a week trying to figure out why the eGPU isn't connecting/disconnecting. But if you're using a portable MacBook Pro that you're connecting every day, I wouldn't recommend it. I had a good performance boost using Photoshop and Maya. I know this is about games, but I wanted to relay my experience using an eGPU (using the Razer enclosure and an AMD RX Vega 64) in a professional context.
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